After Megamind, a highly intelligent alien supervillain, defeats his long-time nemesis Metro Man, Megamind creates a new hero to fight, but must act to save the city when his "creation" becomes an even worse villain than he was.
The ongoing war between the canine and feline species is put on hold when they join forces to thwart a rogue cat spy with her own sinister plans for conquest.
Dave Lizewski is an unnoticed high school student and comic book fan who one day decides to become a super-hero, even though he has no powers, training or meaningful reason to do so.
Aimee Dent had to grow up fast. She is raising her little brother all on her own. But her life is changed forever when she meets a teenage boy who gives her a taste of what it's like to be a kid again.