916 as the name suggests focuses mainly on the relationship between a single father, Dr. Harikrishnan(Anoop Menon), and his 12th grade daughter Meera(Malavika Menon). It narrates the events of two closely knit families losing their balance; Harikrishnan's, and Dr. Ramesh's (Mukesh), his wife(Meera Vasudev) and their two children. While Dr. Harikrishnan is an altruist who considers his profession a means to serve society, Dr. Ramesh thinks otherwise. Prasanth(Asif Ali) appears as a romantic interest of Meera, leading her astray into the world of malls, cellphones, and the Internet. The movie comes to a twist when Meera goes missing. 
Four tales unfold in the Eternal City: While vacationing in Rome, architect John encounters a young man whose romantic woes remind him of a painful incident from his own youth; retired opera director Jerry discovers a mortician with an amazing voice, and he seizes the opportunity to rejuvenate his own flagging career; a young couple have separate romantic interludes; a spotlight shines on an ordinary man.
When an evil spirit known as Pitch lays down the gauntlet to take over the world, the immortal Guardians must join forces for the first time to protect the hopes, beliefs and imagination of children all over the world.
Jill Parrish is trying to rebuild her life after surviving a terrifying kidnapping attempt. Though she is having a difficult time, she takes small steps toward normalcy by starting a new job and inviting her sister, Molly, to move in with her.