China, Jiangsu province, the present day. On 15 October, after depositing the funerary urn of his father, Professor Gu Daqing (Feng Dalu), who died of a sudden heart attack, Gu Jie (Calvin Yu) receives a phone call from a stranger telling him the urn has just been stolen and to "remember the 19th." After his car is hit by a lorry, Gu Jie wakes up on the 16th on the seashore of an island, where he finds a kidnapped girl tied up nearby. The girl's father, Jia Kuan (Li Hongquan), arrives and tells him to leave the island. In his pocket, Gu Jie finds a key to Room 327 of Shun Lai Hotel. After meeting a girl, Nana (Nancy Liu), who has a heart condition and whom his father once treated, Gu Jie goes to the decrepit hotel and checks into the room, where he finds an animal head in the bed and an old photo of a boy. "Welcome to the game," says the mysterious phone caller.
Four tales unfold in the Eternal City: While vacationing in Rome, architect John encounters a young man whose romantic woes remind him of a painful incident from his own youth; retired opera director Jerry discovers a mortician with an amazing voice, and he seizes the opportunity to rejuvenate his own flagging career; a young couple have separate romantic interludes; a spotlight shines on an ordinary man.
A veteran chef faces off against his restaurant group's new CEO, who wants to the establishment to lose a star from its rating in order to bring in a younger chef who specializes in molecular gastronomy.
Jill Parrish is trying to rebuild her life after surviving a terrifying kidnapping attempt. Though she is having a difficult time, she takes small steps toward normalcy by starting a new job and inviting her sister, Molly, to move in with her.