In 1926, Newt Scamander arrives at the Magical Congress of the United States of America with a magically expanded briefcase, which houses a number of dangerous creatures and their habitats.
Set after the events of Continental Drift, Scrat's epic pursuit of his elusive acorn catapults him outside of Earth, where he accidentally sets off a series of cosmic events that transform and threaten the planet.
Mia, an aspiring actress, serves lattes to movie stars in between auditions and Sebastian, a jazz musician, scrapes by playing cocktail party gigs in dingy bars, but as success mounts they are faced with decisions that begin to fray the fragile fabric of their love affair, and the dreams they worked so hard to maintain in each other threaten to rip them apart.
After a self-destructive lifestyle nearly kills her, tormented young Anne learns to open up and let go of her traumatic past through a new found passion for boxing.
Carlos is an ex-con looking for a job where he earns a lot of money without having to work hard. After discussing it with his cellmate, they conclude that the only work to fit the description is to be politician in Puerto Rico.
1966, United States of America: Kennedy is unable to prevent the Cuban Missile crisis in 1962, creating a nuclear winter throughout the country that seems to have no end.