Forty years after the events of the first Spaceballs, the galaxy is once again under threat. A threat so evil, so unstoppable, so completely lacking in any original ideas, that it has vowed to bring back the past.
Yuri Orlov, the world's most famous arms dealer, discovers that he has a son, Anton who is trying to outdo his father by raising an army of mercenaries to fight in America's Middle Eastern conflicts, triggering a father-son rivalry.
Two fugitive animals embark on an adventure across America to find the ranch that was once their home, healing their friendship while pursued by an equally "odd-couple" DEA agent and Fish and Wildlife ranger with something to prove.