Woman Against Woman is a tale of two sisters. Bessie, the older and more sensible one, is forever losing her boyfriends to Miriam, the younger, prettier and flightier of the two.
Aggie has survived the measles, mumps and scarlet rash, so when she brought home the high school diploma her parents thought she was a young lady now and couldn't catch anything more.
In search of a maid, Mrs. Cook, an aristocratic and extremely proud society woman, goes to an employment agency and hires Luna, fat, awkward and straight from Sweden.
Broncho Billy shoots an outlaw for making a disrespectful remark about his sweetheart. After the shooting he hastens to her home and tells her he has shot a man, but does not know who he is.
Captain Lanning and Lieutenant Osborne are stationed at an army post in the Philippines. Lanning conceives a deadly hatred toward Osborne when the latter wins Gladys, General Fields' daughter.
This twenty-three episode serial told the story of a secret society called The Black Hundred and its attempts to gain control of a lost million dollars.