Dalton, a promising young doctor, becomes infatuated with a dancer named La Stella who introduces him to drugs, and he becomes a morphine addict. His addiction leads to the death of a child due to a fatal medical error while he is under the influence, ultimately ruining his career.
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Mark Stetson, a scheming politician, entangles the Brandons, husband and wife, and their friend, Antoinette, in his smuggling schemes and engineers their arrest, to protect himself.
Irving Lawrence owns some of the most decrepit tenements in town and is an all-around bad guy. He won't cooperate with the efforts of his wife, Barbara, to help the poor and sees other women behind her back.
A banker, after a prophetic meeting with a Gypsy fortune teller, becomes delusional as he searches for a trunk which the seer has told him holds the key to either his happiness or his death.
Margot Sperry, who keeps house for her guardian, a professor who wants to revert to primitive modes of living, finds it difficult to find food in the winter wilderness and resorts to pilfering from the Bates's winter camp.
A man neglects his wife to be with a dance hall singer. When the truth of his infidelity reaches his wife and the truth of his marital status reaches his lover, both women are heartbroken.
John Keefe, a gambler, shoots and kills Robert Barrington in an argument over a card game. Keefe steals Barrington's papers and forges a bill of sale to himself for Barrington's stable of race horses back east.
The Devil, in the guise of a human, meets a young couple who remark upon looking at a Renaissance painting of a martyr that Evil could never triumph over Good.
Movie mogul Thomas H. Ince may well have been the director of The Despoiler as indicated by the credits; but since Ince was known far and wide as a glory-hogger, it's also possible that one of his talented lieutenants wielded the megaphone.
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