Molly Boone's father has been sent to prison for twenty years for alleged complicity in the killing of a revenue officer, Uriah Hudson, whom she secretly suspects of having a hand in sending her father to prison, is her persistent suitor.
The second of Thomas Meighan's three 1927 vehicles, We're All Gamblers was also the first of two collaborations between Meighan and director James Cruze.
The story revolves around a young woman named Lenore Vance (Mabel Forrest), who loses her memory after witnessing the death of her father Silas Gregg (William H Turner).
Bill Pike, recently married, hits his home town about seven in the evening, and immediately is seized by a bunch of his old cronies who drag him into a hotel to have a game of poker.
A blind woman is cured by a doctor, but when her sight is restored she accidently mistakes her kind lover for his wayward younger brother and no one deems to correct her ‘fearing for her psyche’.
Movie mogul Thomas H. Ince may well have been the director of The Despoiler as indicated by the credits; but since Ince was known far and wide as a glory-hogger, it's also possible that one of his talented lieutenants wielded the megaphone.