Eccentric consulting detective Sherlock Holmes and Doctor John Watson battle to bring down a new nemesis and unravel a deadly plot that could destroy England.
Susan Cushing asks Holmes' help in solving the disappearance of her sister Mary Browner, but it doesn't seem Holmes' type of case until he is told of a Christmas present's grisly contents.
Sherlock Holmes and Dr. Watson meet as boys in an English Boarding school. Holmes is known for his deductive ability even as a youth, amazing his classmates with his abilities.
When a bored Sherlock eagerly takes the case of Gabrielle Valladon following an attempt on her life, the search for her missing husband leads to Loch Ness and the legendary monster.
After the death of his wife, retired judge Justin Playfair creates a fantasy world for himself in which he is the legendary detective Sherlock Holmes, even dressing like the character.
Having once again avoided criminal conviction, Professor Moriarity develops a murderous plan to “finish off” his last major nemesis, Sherlock Holmes, by making him fail to prevent the perfect crime.
Holmes and Watson board a passenger train bound from London to Edinburgh, to guard the Star of Rhodesia, an enormous diamond worth a fortune belonging to an elderly woman of wealth; but within the first hour of the trip, the woman's son is murdered and the diamond stolen and any of the passengers in their car could be the killer thief.
Sherlock Holmes investigates a series of so-called "pajama suicides". He knows the female villain behind them is as cunning as Moriarty and as venomous as a spider.
The gang is trying just about anything to pass the time during their summer vacation. As usual, Mickey and Jack are trying to win the affections of Mary.
Jane Maynard opens a mission in memory of philanthropist Bland Hendricks. John Anstell, son of a powerful and selfish millionaire, Michael Anstell, falls in love with Jane, to the old man's disapproval.
Automobile maker John Kent is an old-fashioned sort who refuses to advertise his car line. His daughter Ginger, however, is determined to get him some publicity and goes speeding around town in one of his cars, hoping to get arrested.
"Katy" Didd holds up the stage in which his sweetheart, Alice Mason, is traveling to her wedding to Prince Tetlow, to whom her guardian insists that she be married.