Jeud is a young man deceived by love. With all the money he has left, he buys a car in order to go on a road trip. By chance, he picks up two people who go along with him.
Wyatt and Billy, two Harley-riding hippies, complete a drug deal in Southern California and decide to travel cross-country in search of spiritual truth.
Long-haul driver Hannes picks up a young hitchhiker, Herb, who had a falling-out with his parents after dropping out of college and now travels around doing odd jobs.
Patagonia narrates the journeys of two women - one looking for her past, the other for her future. The film inter-cuts between their stories, in which one of them travels south to north through the Welsh springtime and the other east to west through the Argentine autumn.
Michael is supposed to go to prison for 18 months, but escapes from the police officer. On the run, he meets Malika, who has also committed "stupid things.
Vincent, a down-at-the-heels French cab driver, desparately in need of cash for child support is intrigued when Thelma charters his cab for a trip to Crete.
Nina Kern, a divorced woman in her late twenties, will soon be fully deprived of her custody rights for her three children, who already reside in a home for the displaced due to Nina’s many years of willful neglect.