Sam Wheat is a banker, Molly Jensen is an artist, and the two are madly in love. However, when Sam is murdered by his friend and corrupt business partner Carl Bruner over a shady business deal, he is left to roam the earth as a powerless spirit.
A couple encounters a perverted gas station attendant who threatens them with a shotgun. They take a deserted path in Texas to seek help, but only meet up with a cannibalistic clan interested in helping themselves to fresh meat.
Hick handymen Val McKee and Earl Bassett can barely eke out a living in the Nevada hamlet of Perfection, so they decide to leave town -- despite an admonition from a shapely seismology coed who's picking up odd readings on her equipment.
Wounded Civil War soldier, John Dunbar tries to commit suicide – and becomes a hero instead. As a reward, he's assigned to his dream post, a remote junction on the Western frontier, and soon makes unlikely friends with the local Sioux tribe.
Just north of London live Wendy, Andy, and their twenty-something twins, Natalie and Nicola. Wendy clerks in a shop, leads aerobics at a primary school, jokes like a vaudevillian, agrees to waitress at a friend's new restaurant and dotes on Andy, a cook who forever puts off home remodeling projects, and with a drunken friend, buys a broken down lunch wagon.
Sylvia's work increasingly takes her away from the three men who help bring up Mary, her daughter. When she decides to move to England and take Mary with her, the three men are heartbroken at losing the two most important females in their lives.