It's late 17th century. The viola da gamba player Monsieur de Sainte Colombe comes home to find that his wife died while he was away. In his grief he builds a small house in his garden into wich he moves to dedicate his life to music and his two young daughters Madeleine and Toinette, avoiding the outside world. Rumor about him and his music is widespread, and even reaches to the court of Louis XIV, who wants him at his court in Lully's orchestra, but Monsieur de Sainte Colombe refuses. One day a young man, Marin Marais, comes to see him with a request, he wants to be taught how to play the viol.
Amidst her own personality crisis, southern housewife Evelyn Couch meets Ninny, an outgoing old woman who tells her the story of Idgie Threadgoode and Ruth Jamison, two young women who experienced hardships and love in Whistle Stop, Alabama in the 1920s.
Bored with her marriage to burnt out poet turned corporate executive Thierry, Zandalee falls prey to an old friend of her husband, the manipulative and egotistical Johhny and becomes enmeshed in a sensual, passionate and destructive affair.
Whilst on a short weekend getaway, Louise shoots a man who had tried to rape Thelma. Due to the incriminating circumstances, they make a run for it and thus a cross country chase ensues for the two fugitives.
This bizarre surrealistic black comedy takes place in a small fictitious post-apocalyptic town where food is scarce and butcher Clapet has the macabre business of using human flesh to feed his customers.