The story told in Souls in Torment begins with a well-known urban legend (a characteristic that one of the characters in the film emphasizes). Mélinton (Edgar Palomino), a young truck driver, picks up a woman on the highway who appears in the middle of the night and asks him to take her to a nearby town. He takes her and agrees to meet her the next day, later discovering that the woman in question had died a year earlier, which triggers a series of events marked by the horror of the supernatural experience.
In the 1920s, former coal miner Harry Hoxsey claimed to have an herbal cure for cancer. Although scoffed at and ultimately banned by the medical establishment, by the 1950s, Hoxsey's formula had been used to treat thousands of patients, who testified to its efficacy.
In 2019, Lincoln Six-Echo is a resident of a seemingly "Utopian" but contained facility. Like all of the inhabitants of this carefully-controlled environment, Lincoln hopes to be chosen to go to The Island — reportedly the last uncontaminated location on the planet.
In Seattle, detective Quentin Conners is unfairly suspended and his partner Jason York leaves the police force after a tragic shooting on Pearl Street Bridge, when the hostage and the criminal die.
After terrorizing the people of Nodaway County and repeatedly escaping justice for years, the town bully finally meets his demise at the hands of the townspeople of Skidmore, Missouri.
John Constantine has literally been to Hell and back. When he teams up with a policewoman to solve the mysterious suicide of her twin sister, their investigation takes them through the world of demons and angels that exists beneath the landscape of contemporary Los Angeles.
Emma (Damasus-Aboderin), Candace (Genevieve Nnaji) and Yvonne (Jalade-Ekeinde) have been friends since High School and have since settled into their respective lifestyles.