Moon is a young misfit who has the ability to talk to bugs. Moon has always been perceived as a "misfit" because she spoke baby talk too long. She has a crush on a boy named Hyland who works in a store across the street from her house. Unknown to Moon, Hyland has a serious problem with body contact with other people. Moon also meets Coochie, an endearing ladybug who speaks to her and becomes part of her daily life, advising her. Moon meets a band of kids who also has abilities, including telekinetic twins, a high jumping teen, a fortune teller, a boy with x-ray vision that is a semi-pervert. Leading these misfits is a woman named Auntie who looks early to mid 20s but her actual age is 70. Auntie wants both Moon and Hyland to join her band of misfits because of Moon's abilities and Hyland's ability to dodge other people's attacks.
Ray Ferrier is a divorced dockworker and less-than-perfect father. Soon after his ex-wife and her new husband drop of his teenage son and young daughter for a rare weekend visit, a strange and powerful lightning storm touches down.
Psychiatrist Sam Foster has a new patient, Henry Letham, who claims to be suicidal. In trying to diagnose him, Sam visits Henry's prior therapist and also finds Henry's mother -- even though Henry has said that he murdered both of his parents.
When the sky really is falling and sanity has flown the coop, who will rise to save the day? Together with his hysterical band of misfit friends, Chicken Little must hatch a plan to save the planet from alien invasion and prove that the world's biggest hero is a little chicken.