In attempting to develop a chemical which would make a person super-intelligent, Dr. Montrose fails and the subjects of his experiments metamorphose into hideous monsters who band together and prey on humans. With the police stymied, a young detective attempts to track down the leader of the group of killers, known only to have a small crimson stain in one eye.
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The mysterious Count Orlok summons a happily married real estate agent to his castle, located up in the Transylvanian mountains, to finalise a terrifying deal.
A film projectionist longs to be a detective, and puts his meager skills to work when he is framed by a rival for stealing his girlfriend's father's pocketwatch.
In 16th-century Prague, a rabbi creates the Golem - a giant creature made of clay. Using sorcery, he brings the creature to life in order to protect the Jews of Prague from persecution.
The nefarious Dr. Fu Manchu searches for the keys to the tomb of Genghis Khan, in order to fulfill a prophecy that will enable him to conquer the world.
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Accused of stealing the annual report of the Great Western Railroad Dick Olney is discharged though it was really the president’s secretary Hodges who took it to sell information to the opposition.
Prof. Alonzo Bozzle, an eccentric zoologist, has taken up the study of evolution as promulgated by Darwin and is pondering especially on the idea that there is a "missing link.
Muriel Flemming secretly marries Graydon Burton before he heads West to make his fortune. Later, when he is about to board a train to return to his wife, he is accused of a murder that was actually committed by crooked attorney Herman Slade.
Jim Blake, the playboy son of a New York millionaire, heads west to prove himself a man. He goes to work on his father's ranch in Wyoming, and eventually wins over the locals by turning the tables on a town bully and trying to collect damages from a railroad magnate, whose trains have killed many of the Blake ranch's cattle.
Fatima decides she needs to reduce her weight. Inspired by the example of famous actress and beauty icon Lillian Russell, she attempts to "roll it off" through various weight-loss methods.
In the future (1921), an alliance of several foreign countries plot to attack the US. American officials, coming to the realisation that the country is basically defenceless, offer $1,000,000 to anyone who can come up with a weapon to defeat the invaders.
